In vitro engineering of functional myocardium

Within this line of research, the Medical Cell Biology Research Group focuses on the in vitro engineering of functional myocardium that mimics human heart tissue for analysis of myocardial function:

  • Differentiation of human pluripotent stem cells into functional cardiomyocytes and study of different genetic heart diseases with the help of induced pluripotent stem cell (iPSC) technology.
  • Dysfunction of the myocardium may result from complicated interactions between various cell types, thus more complex heart models are needed. Our objective is to mimic this interaction by creating a 3D co-culture of all cell types that make up the heart, including the cardiac fibroblasts that synthesize the ECM, to gain a deeper understanding of this interaction.
  • Cultivation of cardiomyocytes with different biomaterials and characterization of the functional properties thereof.

Research project

Human stem cell-derived models to unveil mechanisms of impaired myocardial function in Marfan Syndrome


Exploring molecular mechanisms underlying arrhythmogenic cardiomyopathy using human-engineered heart tissue




  • Jolanda van Hengel, principal investigator